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This concise overview of renal physiology introduces basic science principles and their relevance in the clinical expression of disease. Each chapter incorporates a wealth of pedagogical aids including: study questions, learning objectives, and clinical examples. Also serves as a good review for the USMLE Step 1.

作者简介：

Douglas C. Eaton, Ph.D.: Distinguished Professor, Department of Physiology; and Director, Center for Cell and Molecular Signaling, Emory University Medical School, Atlanta John Pooler, Ph.D.: Associate Professor of Physiology, Department of Physiology, Emory University Medical School, Atlanta .

Preface

Chapter 1 Renal Functions,Snatomy,and Basic Processes

　Functions

　Anatomy of the Kidneys and Urinary System

　The Nephron

　Blood Supply to the Nephrons

　Basic Renal Processes

Chapter 2 Renal Blood Flow and Glomerular Filtration

　Glomerular Filtration and Renal Blood Flow

　Flow, Resistance, and Pressure in The Kidneys

　Glomerular Filtration

　Autoregulation

Chapter 3 Clearance

　Clearance Units

　Plasma Creatinine and Urea Concentrations as Indicators of GFR Changes

Chapter 4 Basic Transport Mechanisms

　Crossing the Epithelial Barriers

　Receptor-Mediated Endocytosis and Transcytosis

　Transport Mechanisms in Reabsorption

Chapter 5 Renal Handling of Organic Substances

　Active Proximal Reabsorption of Organic Nutrients (Eg, Glucose, Amino Acids)

　Proteins and Peptides

　Active Proximal Secretion of Organic Anions

　Active Proximal Secretion of Organic Cations

　pH Dependence of Passive Reabsorption or Secretion Urea

Chapter 6 Basic Renal Processes for Sodiun,Chloride,and Water

　Overview

　Individual Tubular Segments

　Urinary Concentration: The Medullary Osmotic Gradient

Chapter 7 Control of Sodium and Water Excretion:Regulation of Plasma Volume and Plasma Osmolality and Renal Control of Systemic Blood Pressure

　Regulation of Blood Pressure

　Contribution of The Kidney to The Long-Term Regulation of Blood Pressure

　Control of Sodium Balance

　Control of Water Excretion

Chapter 8 Renal Regulation of Potassium Balance

　Regulation of Potassium Between the Intracellular and Extracellular Compartments

　Renal Potassium Handling

Chapter 9 Regulation of Hydrogen Ion balance

　Guidelines for Studying Acid-Base Biology

　Renal Handling of Acids and Bases

　Renal Excretion of Acid and Base

　Hydrogen Ion Excretion on Urinary Buffers

　Phosphate and Organic Acids as Buffers

　Hydrogen Ion Excretion on Ammonium

　Quantification of Renal Acid-Base Excretion

　Regulation of the Renal Handling of Acids and Bases

　Control of Renal Glutamine Metabolism and NH4 Excretion

　Intravenous Solutions: Lactated Ringer's

　Specific Categories of Acid-Base Disorders

　Renal Response to Metabolic Acidosis and Alkalosis

　Factors Causing the Kidneys to Generate or Maintain

　A Metabolic Alkalosis

Chapter 10 Regulation of Calcium and phosphate Balance

　Effector Sites for Calcium Balance

　Hormonal Control of Effector Sites

　Overview of Renal Phosphate Handling

Answers to Study Questions

Appendix A

Appendix B

Index

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书籍介绍

This concise overview of renal physiology introduces basic science principles and their relevance in the clinical expression of disease. Each chapter incorporates a wealth of pedagogical aids includin