G&G’S PHARMACOLOGICAL BASIS OF THERAPEUTGOODMAN&GILMAN治疗学的药理学基础 fb2 pdf azw3 网盘 rtf 免费 下载 txt

There are few technical books that remain in a leadership position for 65 years. The Pharmacological Basis of Therapeutics is one. Physicians, teachers, and medical students have voted for Goodman & Gilman with their feet and with their pocketbooks for over six decades. The question is not whether this is an important and useful text, but why?

A sentence by the original authors in their 1940 preface still describes the 11th edition: “This book has also been written for the practicing physician, to whom it offers an opportunity to keep abreast of recent advances in therapeutics and to acquire the basic principles necessary for the rational use of drugs in his/her daily practice.” The book’s 65 chapters are grouped into 15 sections: General Principles, Drugs Acting at Synaptic and Neuroeffector Junctional Sites, Drugs Acting on the Central Nervous System, Drug Therapy of Inflammation, Drugs Affecting Renal and Cardiovascular Function…Chemotherapy of Microbial Diseases, Chemotherapy of Neoplastic Diseases…Hormones and Hormone Antagonists, Dermatology, Ophthalmology, Toxicology, plus two appendices on pre*ion writing and patient compliance, and on the design of dosage regimens.

Reading the sections on general principles reminds one that, with the notable exception of antimicrobial and antiparasitic therapy, pharmacology is the science of altering human physiology by chemical means. The well-written chapter on treating hypertension illustrates this concept nicely; it is a pleasure to read and a vast improvement over the PDR or drug company ads. So too is the chapter on principles of antimicrobial therapy. Given the large number of authors, some chapters are easier to read than others, but none can be faulted for lack of well-organized and referenced information. Comparison of the current edition with the fifth edition of only 30 years ago provides an interesting insight into changing times. Then, the great Louis Weinstein personally wrote all the chapters on antimicrobial agents. In the current edition, five experienced and specialized physicians are required for that task.

Contributors

Consultants to the Editors

Preface

Preface to the First Edition

SECTION I　GENERAL PRINCIPLES

　1. Pharmacokinetics and Pharmacodynamics: The Dynamics of Drug Absorption, Distribution, Action, and Elimination

　2. Membrane Transporters and Drug Response

　3. Drug Metabolism

　4. Pharmacogenetics

　5. The Science of Drug Therapy

SECTION II　DRUGS ACTING AT SYNAPTIC AND NEUROEFFECTOR JUNCTIONAL SITES

　6. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems

　7. Muscarinic Receptor Agonists and Antagonists

　8. Anticholinesterase Agents

　9. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia

　10. Adrenergic Agonists and Antagonists

　11. 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists

SECTION III　DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM

　12. Neurotransmission and the Central Nervous System

　13. General Anesthetics

　14. Local Anesthetics

　15. Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium

　16. Hypnotics and Sedatives

　17. Drug Therapy of Depression and Anxiety Disorders

　18. Pharmacotherapy of Psychosis and Mania

　19. Pharmacotherapy of the Epilepsies

　20. Treatment of Central Nervous System Degenerative Disorders

　21. Opioid Analgesics

　22. Ethano

　23. Drug Addiction and Drug Abuse

SECTION IV　AUTACOIDS: DRUG THERAPY OF INFLAMMATION

　24. Histamine, Bradykinin, and Their Antagonists

……

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This is a Doody's core title. It is an essential purchase. It got 5 star rating in Doody's review. 'The 11th edition of Goodman & Gilman continues to be the most comprehensive and authoritative single source on the pharmacology of drugs. The first edition was published by Alfred Gilman and Louis Goodman in 1941. It soon became known as the bible of pharmacology and, even though editorship and chapter authorships have changed continuously from edition to edition, this remains the gold standard of pharmacology textbooks...The print version should be on the reference shelf and the digital version on the computer desktop of all practicing pharmacologists, pharmacists, and physicians' - "Doody's Review Service".