纳米药物-多功能聚合物药物递送系统研究(英文版) fb2 pdf azw3 网盘 rtf 免费 下载 txt

本书为全英文学术专著，主要介绍刺激响应聚合物和聚合物杂化纳米药物载体的设计、制备、表征和应用。全书包括四章， 章主要介绍纳米药物传递体如何实现跨越生物学屏障，改善药物分布，实现治疗的靶向；第二章主要介绍中空介孔硅材料作为载体的三重刺激响应药物释放系统；第三章主要介绍以中空介孔硅为载体的光热－化学联合治疗材料；第四章描述了以两亲聚合物作为载体的叶酸靶向光热－化学联合治疗聚合物材料。

Chapter 1 INTRODUCTION

1.1 Nanoparticles in Drug Delivery

1.1.1 Role of nanoparticles in drug delivery

1.1.2 Composition of drug delivery nanocarriers

1.1.3 FDA-approved therapeutic nanoagents

1.2 Design Rules for Targeted Drug Delivery Nanoplatform

1.2.1 Stimuli-responsive drug release

1.2.2 Biocompatibility and biodegradability

1.2.3 Stability, size and targeting

1.3 Photothermal Therapy

1.3.1 NIR induced photothermal therapy

1.3.2 NIR absorbing materials for photothermal therapy

1.3.3 Polymer for the delivery of NIR-absorbing dye

1.3.4 Combined photothermal-chemotherapy

Chapter 2 POLYMER-COATED HOLLOW MESOPO-ROUS SILICA NANOPARTICLES FOR TRIPLE-RESPONSIVE DRUG DELIVERY

2.1 Introduction

2.2 Materials and Methods

2.2.1 Preparation of o-nitrobenzyl linkage

2.2.2 Preparation of PDEAEMA coated HMSNs

2.2.3 Preparation of DOX-loaded nanoparticles

2.2.4 Drug release behavior

2.2.5 Cellular uptake study

2.2.6 Cytotoxicity study

2.3 Results and Discussiona

2.3.1 Preparation of HMSNs-PDEAEMA

2.3.2 Loading and triggered release of DOX

2.3.3 Cellular uptake and intracellular release

2.3.4 In vitro antimmor study

2.4 Conclusion

Chapter 3 POLYMERIC PRODRUG GRAFTED HOLLOW MESOPOROUS SILICA NANOPAR-TICLES ENCAPSULATING NIR-ABSOR BING

DYE FOR POTENT COMBINED PHOTOTHERMAL-CHEMOTHERAPY

3.1 Introduction

3.2 Materials and Methods

3.2.1 Synthesis of HMSNs-RAFT

3.2.2 HMSNs-DOX prodrug

3.2.3 Preparation of HMSNs-DOXIP

3.2.4 Drug release, dye loading and photothermal effect

3.2.5 Cellular uptake study

3.2.6 In vitro cytotoxicity study

3.3 Results and Discussion

3.3.1 Synthesis and characterization of HMSNs-DOX

3.3.2 Drug release, dye loading and photothermal effects

3.3.3 Cellular uptake and intracellular release

3.3.4 In vitro antitumor study

3.4 Conclusion

Chapter 4 ACID-SENSITIVE POLYMERIC DOXORUBICIN PRODRUG MICELLES ENCAPSULATING NEAR-INFRARED DYE FOR

TARGETED COMBINED PHOTOTHERMAL-CHEMOTHERAPY

4.1 Introduction

4.2 Materials and Methods

4.2.1 Synthesis of block copolymer

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